I'm desesperated. Options

[americancoffee]

Hi!:)
Well, first, I have to say i'm new here, and the reason
I've done a new topic is because, like its tittle says, I'm desesperated. Why? Because since one week ago I'm googleing all the time to find something about how to create a layout.
I know all consist in HTML and CSS, but really I'm confused.
How do you do to make these layouts?
Really I've seen some layouts which they have let KO. They are fabuluous.
I though there should be some programme which helps to you to create them, but almost of the times I've found that only is to know SOMETHING about CSS. How do you organize with so many unexplained words?

¿Are there someone who can help me with it?
Really I want to learn to create this things, I need it :(

Thank you.

Daphne.