How to Make It in America follows two enterprising twenty-somethings hustling their way through New York City's fashion scene, determined to achieve their version of the American Dream. Trying to make a name for themselves in the city's competitive fashion scene, Ben Epstein and his friend and business partner Cam Calderon use their street knowledge and connections to make their way up. With the help of their well-connected friend Domingo and Cam's cousin Rene, who has ambitions of his own—a new energy drink called Rasta-Monsta—the burgeoning entrepreneurs set out to make it big.